Analysis of Application Development of Drying Equipment in Pharmaceutical Industry

Drying equipment, also known as dryers and dryers. The equipment used for the drying operation vaporizes the moisture (generally refers to moisture or other volatile liquid components) in the material by heating to obtain a solid material with a predetermined moisture content. The purpose of drying is for material use or further processing needs. For example, the drying of wood before the production of wooden molds and woodware can prevent the deformation of the product. The drying of the ceramic blank before calcining the two drying equipments can prevent the finished product from cracking. In addition, the dried material is also easy to transport and store, such as drying the harvested grain to a certain moisture content to prevent mildew. Since natural drying is far from meeting the needs of production development, various mechanized dryers are being applied more and more widely.

In order to better reduce costs, increase production efficiency, and reduce the labor intensity of workers in the pharmaceutical process, according to foreign technical data, in 2000 it developed its own filtration, washing, and drying "triple play" equipment. The equipment can complete filtration, washing (bleeding), and drying in a sealed container. At the same time, it replaces filtration and drying equipment. It can achieve continuous operation in the whole closed and full process, and is more suitable for products requiring asepsis. The production of toxic products.

With the rapid development of society, people are increasingly demanding drugs. Although Western European countries have advanced technology and equipment, due to their high requirements for environmental protection and high wages of the labor force, the high operating costs make it difficult for these countries to maintain the continuous production of APIs and intermediates. Gradually form the trend of foreign pharmaceutical companies investing and setting up factories in developing countries. Undoubtedly, China is an ideal country to invest in, with sufficient manpower and material resources. In recent years, China's pharmaceutical industry has made considerable progress.

GMP's drug regulations expressly state that all pharmaceutical equipment must comply with GMP production requirements and must be capable of in-situ cleaning and in-situ sterilization. During the operation of the equipment, there must be no secondary pollution to the medicine. To address this requirement, we use a positive pressure drying process for low-energy aseptic spray drying equipment. 0.5u of dust particles in the hot air entering the tower does not exceed 10/liter. Operating temperature can be 0--150 °C, using a three-fluid nozzle. The vapor-liquid contact is good and the atomization is even, which meets the aseptic operation requirements. Due to the good contact of the mist and the short drying time, the dry strength can reach about 7 kg (water)/m3•hour.

In order to better reduce costs, increase production efficiency, and reduce the labor intensity of workers in the pharmaceutical process, according to foreign technical data, in 2000 it developed its own filtration, washing, and drying "triple play" equipment. The equipment can complete filtration, washing (bleeding), and drying in a sealed container. At the same time, it replaces filtration and drying equipment. It can achieve continuous operation in the whole closed and full process. It is more suitable for aseptic products. The production of toxic products.

In the filtration stage, the crystal and the mother liquor are separated and operated under pressurized vacuum conditions. The smoothing and compaction of the filter cake through the smoothing of the S-type stirring paddles makes the solid-liquid separation effect better. A special rotating spray device is arranged in the container so that the cleaning liquid is evenly distributed in the container. The internal cleaning of the container and the cleaning of the material can be achieved. Through the rotation and lifting of the stirring blades, the filter cake and the cleaning liquid are mixed more uniformly. The slurry cake was thoroughly washed. The filter cake after suction filtration is scraped and heated by the stirring slurry layer by layer to heat the entire barrel body, the chassis, and the blade to scrape the material. The side discharge device is opened, and the material is automatically discharged from the discharge port on the side of the tank wall through the pushing of the blade.

In order to reduce the investment of equipment and equipment processes in the processing of pharmaceuticals, the company has developed a “five-in-one” device based on double cones, ie, five processes of crystallization, reaction, filtration, washing, and drying in a single device. . One end of the double cone is designed as a circular arc bottom and a stirring blade is designed. In the reaction and crystallization, the cone faces downward, and uniform crystallization and reaction are achieved by stirring the stirring leaves. After crystallization, reaction, the cone was rotated 180°C. At one end of the cone is designed a filter sintered mesh device. After the suction filter is connected, the mother liquor is filtered and the washing solution is passed through the washing interface. The filter cake is washed during the revolving process. After the washing process is completed, as in the double-cone drying process, in order to prevent the material from pilling, the stir-leaf can also be used to start smashing the material. After drying, open the end cap discharge (same double cone) and clean the material at one time. Therefore, this kind of equipment is more practical and combines the advantages of the tank type three-in-one and double-cone.

Closed Cooling Tower

Why say closed cooling tower is energy saving and environmental protection equipment, more and more users are using this kind of equipment to replace the original equipment (open tower), we can through data analysis and comparison, the two energy data accounting can be obvious. Energy consumption is basically two major aspects, one is water, the other is electricity. Both are energy costs that no cooling tower can escape, unless you leave the equipment on.

First of all, look at the consumption of water. Water is generally consumed in two aspects. One is the flying overflow after spraying, and the other is the evaporation consumption of water.

Let's look at the open cooling tower, the spray water of the tower is basically between two and three percent of the overflow rate, if we according to the daily operation of 10 hours, excluding holidays, 280 days of operation. According to the actual open cooling tower flow of 6000 cubic meters per hour to calculate. 6000*2%*10*280= 336,000 tons of water, and the same closed cooling tower, its spray flying overflow is very small, because after all, the spray work is carried out in the tower, almost can be controlled in a few thousandths, we calculate according to 5 thousandths, the same is 10 hours of work, 280 days a year operation, To achieve the same cooling amplitude is basically 4,500 tons per hour of closed cooling tower is enough, then the calculation results: 4,500 *0.5%*10*280= 63,000 tons, it is not difficult to see, because of the different design structure caused by the waste of spraying water resources, more than 200,000 tons of terror. The bigger the pool of the open tower, the more wasted water, because the evaporation area increases, and the closed cooling tower has no pool, so the consumption here is zero. Judging from the price of a ton of water, just such a equipment, a year to solve the capital of hundreds of thousands of enterprises.

Let's look at the comparison of electric energy, electric energy is not different, because they are all through the same power equipment to operate the equipment, the power of the two is similar, the running time is the same, basically the energy consumption is about the same.

To sum up, for the closed cooling tower energy saving accounting can be strong to open the tower out, and, today are advocating energy conservation and environmental protection, this is the general trend, so the closed cooling tower is more and more favored by the majority of users.

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